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Gene: LAT (linker for activation of T cells) Homo sapiens
Symbol: LAT
Name: linker for activation of T cells
Description: Exhibits SH3/SH2 adaptor activity and protein kinase binding activity. Involved in several processes, including integrin-mediated signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Localizes to the Golgi apparatus; immunological synapse; and integral component of membrane. Implicated in primary immunodeficiency disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; IMD52; LAT1; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; p36-38; pp36
Mus musculus (house mouse) : Lat (linker for activation of T cells)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lat (linker for activation of T cells)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lat (linker for activation of T cells)
Pan paniscus (bonobo/pygmy chimpanzee) : LAT (linker for activation of T cells)
Canis lupus familiaris (dog) : LAT (linker for activation of T cells)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lat (linker for activation of T cells)
Sus scrofa (pig) : LAT (linker for activation of T cells)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381628,984,803 - 28,990,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371628,996,147 - 29,002,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,903,648 - 28,909,605 (+)NCBINCBI36hg18NCBI36
Build 341628,904,161 - 28,909,595NCBI
Celera1627,951,162 - 27,957,119 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1626,864,020 - 26,869,977 (+)NCBIHuRef
CHM1_11630,007,898 - 30,013,855 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LAT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342944
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.