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Gene: ZNRF3 (zinc and ring finger 3) Homo sapiens
Symbol: ZNRF3
Name: zinc and ring finger 3
Description: Exhibits frizzled binding activity and ubiquitin-protein transferase activity. Involved in cellular protein metabolic process and negative regulation of Wnt signaling pathway. Localizes to the integral component of plasma membrane; PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; aflatoxin B1; arsenous acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BK747E2.3; CTA-292E10.6; E3 ubiquitin-protein ligase ZNRF3; novel C3HC4 type Zinc finger (ring finger); RING finger protein 203; RING-type E3 ubiquitin transferase ZNRF3; RNF203; zinc/RING finger protein 3
Mus musculus (house mouse) : Znrf3 (zinc and ring finger 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Znrf3 (zinc and ring finger 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Znrf3 (zinc and ring finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ZNRF3 (zinc and ring finger 3)
Canis lupus familiaris (dog) : ZNRF3 (zinc and ring finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Znrf3 (zinc and ring finger 3)
Sus scrofa (pig) : ZNRF3 (zinc and ring finger 3)
Chlorocebus sabaeus (African green monkey) : ZNRF3 (zinc and ring finger 3)
Heterocephalus glaber (naked mole-rat) : Znrf3 (zinc and ring finger 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2228,883,572 - 29,057,488 (+)EnsemblGRCh38hg38GRCh38
GRCh382228,800,657 - 29,057,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,279,755 - 29,453,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,609,890 - 27,783,475 (+)NCBINCBI36hg18NCBI36
Celera2213,079,876 - 13,253,406 (+)NCBI
Cytogenetic Map22q12.1NCBI
HuRef2212,244,792 - 12,417,810 (+)NCBIHuRef
CHM1_12229,238,688 - 29,412,672 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Cell Lines
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ZNRF3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342950
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.