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Gene: EN2 (engrailed homeobox 2) Homo sapiens
Symbol: EN2
Name: engrailed homeobox 2
CRRD ID: 1343015
Description: Exhibits sequence-specific double-stranded DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Localizes to fibrillar center and nucleoplasm. Implicated in autistic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: autism susceptibility 1; AUTS1; engrailed homolog 2; engrailed-2; homeobox protein en-2; homeobox protein engrailed-2; hu-En-2
Mus musculus (house mouse) : En2 (engrailed 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : En2 (engrailed homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En2 (engrailed homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EN2 (engrailed homeobox 2)
Canis lupus familiaris (dog) : EN2 (engrailed homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En2 (engrailed homeobox 2)
Sus scrofa (pig) : EN2 (engrailed homeobox 2)
Chlorocebus sabaeus (African green monkey) : EN2 (engrailed homeobox 2)
Heterocephalus glaber (naked mole-rat) : En2 (engrailed homeobox 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7155,458,129 - 155,464,831 (+)EnsemblGRCh38hg38GRCh38
GRCh387155,458,129 - 155,464,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377155,250,824 - 155,257,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367154,943,585 - 154,950,287 (+)NCBINCBI36hg18NCBI36
Build 347154,748,890 - 154,756,978NCBI
Celera7149,674,408 - 149,681,112 (+)NCBI
Cytogenetic Map7q36.3NCBI
HuRef7148,980,594 - 148,986,984 (+)NCBIHuRef
CHM1_17155,259,197 - 155,265,894 (+)NCBICHM1_1
CRA_TCAGchr7v27154,484,063 - 154,490,767 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on EN2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343015
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.