Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: EN2 (engrailed homeobox 2) Homo sapiens
Analyze
Symbol: EN2
Name: engrailed homeobox 2
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Localizes to the fibrillar center and nucleoplasm. Implicated in autistic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: autism susceptibility 1; AUTS1; engrailed homolog 2; engrailed-2; homeobox protein en-2; homeobox protein engrailed-2; hu-En-2
Orthologs:
Mus musculus (house mouse) : En2 (engrailed 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : En2 (engrailed homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : En2 (engrailed homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : EN2 (engrailed homeobox 2)
Canis lupus familiaris (dog) : EN2 (engrailed homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : En2 (engrailed homeobox 2)
Sus scrofa (pig) : EN2 (engrailed homeobox 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387155,458,129 - 155,464,831 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377155,250,824 - 155,257,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367154,943,585 - 154,950,287 (+)NCBINCBI36hg18NCBI36
Build 347154,748,890 - 154,756,978NCBI
Celera7149,674,408 - 149,681,112 (+)NCBI
Cytogenetic Map7q36.3NCBI
HuRef7148,980,594 - 148,986,984 (+)NCBIHuRef
CHM1_17155,259,197 - 155,265,894 (+)NCBICHM1_1
CRA_TCAGchr7v27154,484,063 - 154,490,767 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on EN2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343015
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.