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Gene: ADAM8 (ADAM metallopeptidase domain 8) Homo sapiens
Symbol: ADAM8
Name: ADAM metallopeptidase domain 8
Description: Exhibits cell adhesion molecule binding activity and metallopeptidase activity. Involved in several processes, including cellular response to hypoxia; positive regulation of membrane protein ectodomain proteolysis; and positive regulation of neutrophil extravasation. Localizes to several cellular components, including cell surface; cytoplasmic vesicle; and podosome. Colocalizes with alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex. Biomarker of asthma; pancreatic ductal carcinoma; and pulmonary eosinophilia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloproteinase domain 8; ADAM 8; CD156; CD156a; cell surface antigen MS2; disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; MGC134985; MS2
Mus musculus (house mouse) : Adam8 (a disintegrin and metallopeptidase domain 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adam8 (ADAM metallopeptidase domain 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam8 (ADAM metallopeptidase domain 8)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM8 (ADAM metallopeptidase domain 8)
Canis lupus familiaris (dog) : ADAM8 (ADAM metallopeptidase domain 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam8 (ADAM metallopeptidase domain 8)
Sus scrofa (pig) : ADAM8 (ADAM metallopeptidase domain 8)
Chlorocebus sabaeus (African green monkey) : ADAM8 (ADAM metallopeptidase domain 8)
Heterocephalus glaber (naked mole-rat) : Adam8 (ADAM metallopeptidase domain 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10133,262,420 - 133,276,868 (-)EnsemblGRCh38hg38GRCh38
GRCh3810133,262,422 - 133,276,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710135,075,920 - 135,090,489 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610134,925,911 - 134,940,362 (-)NCBINCBI36hg18NCBI36
Build 3410134,964,788 - 134,979,211NCBI
Celera10128,426,024 - 128,440,474 (+)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10128,622,621 - 128,637,236 (-)NCBIHuRef
CHM1_110135,357,756 - 135,372,278 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ADAM8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343050
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.