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Gene: ITCH (itchy E3 ubiquitin protein ligase) Homo sapiens
Symbol: ITCH
Name: itchy E3 ubiquitin protein ligase
CRRD ID: 1343086
Description: Exhibits several functions, including arrestin family protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including negative regulation of defense response to virus; positive regulation of receptor catabolic process; and protein ubiquitination. Localizes to nucleoplasm; plasma membrane; and protein-containing complex. Colocalizes with early endosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADMFD; AIF4; AIP4; atrophin-1 interacting protein 4; atrophin-1-interacting protein 4; dJ468O1.1; dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)); E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; itchy E3 ubiquitin protein ligase homolog; itchy homolog E3 ubiquitin protein ligase; NAPP1; NFE2-associated polypeptide 1; ubiquitin protein ligase ITCH
Mus musculus (house mouse) : Itch (itchy, E3 ubiquitin protein ligase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itch (itchy E3 ubiquitin protein ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itch (itchy E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITCH (itchy E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : ITCH (itchy E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itch (itchy E3 ubiquitin protein ligase)
Sus scrofa (pig) : ITCH (itchy E3 ubiquitin protein ligase)
Chlorocebus sabaeus (African green monkey) : ITCH (itchy E3 ubiquitin protein ligase)
Heterocephalus glaber (naked mole-rat) : Itch (itchy E3 ubiquitin protein ligase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2034,363,241 - 34,540,748 (+)EnsemblGRCh38hg38GRCh38
GRCh382034,363,273 - 34,511,773 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372032,951,041 - 33,099,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,414,745 - 32,562,858 (+)NCBINCBI36hg18NCBI36
Build 342032,414,744 - 32,562,858NCBI
Celera2029,700,532 - 29,848,669 (+)NCBI
Cytogenetic Map20q11.22NCBI
HuRef2029,732,695 - 29,880,133 (+)NCBIHuRef
CHM1_12032,852,140 - 33,000,778 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITCH
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343086
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.