Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SHROOM2 (shroom family member 2) Homo sapiens
Symbol: SHROOM2
Name: shroom family member 2
Description: This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apical protein, Xenopus laevis-like; apical protein-like (xenopus laevis); apical-like protein; APX homolog of Xenopus; APXL; DKFZp781J074; FLJ39277; HSAPXL
Mus musculus (house mouse) : Shroom2 (shroom family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shroom2 (shroom family member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shroom2 (shroom family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHROOM2 (shroom family member 2)
Canis lupus familiaris (dog) : SHROOM2 (shroom family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shroom2 (shroom family member 2)
Sus scrofa (pig) : SHROOM2 (shroom family member 2)
more info ...
Related Pseudogenes: SHROOM2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X9,786,406 - 9,949,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X9,754,496 - 9,917,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X9,714,496 - 9,877,481 (+)NCBINCBI36hg18NCBI36
Build 34X9,564,231 - 9,727,217NCBI
CeleraX13,926,415 - 14,088,764 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX7,649,792 - 7,749,592 (+)NCBIHuRef
CHM1_1X9,784,898 - 9,947,903 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SHROOM2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343092
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.