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Gene: SHROOM2 (shroom family member 2) Homo sapiens
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Symbol: SHROOM2
Name: shroom family member 2
Description: This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apical protein, Xenopus laevis-like; apical protein-like (xenopus laevis); apical-like protein; APX homolog of Xenopus; APXL; DKFZp781J074; FLJ39277; HSAPXL
Orthologs:
Mus musculus (house mouse) : Shroom2 (shroom family member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shroom2 (shroom family member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shroom2 (shroom family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SHROOM2 (shroom family member 2)
Canis lupus familiaris (dog) : SHROOM2 (shroom family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shroom2 (shroom family member 2)
Sus scrofa (pig) : SHROOM2 (shroom family member 2)
more info ...
Related Pseudogenes: SHROOM2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X9,786,406 - 9,949,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X9,754,496 - 9,917,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X9,714,496 - 9,877,481 (+)NCBINCBI36hg18NCBI36
Build 34X9,564,231 - 9,727,217NCBI
CeleraX13,926,415 - 14,088,764 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX7,649,792 - 7,749,592 (+)NCBIHuRef
CHM1_1X9,784,898 - 9,947,903 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SHROOM2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343092
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.