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Gene: TBX22 (T-box transcription factor 22) Homo sapiens
Symbol: TBX22
Name: T-box transcription factor 22
Description: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABERS; cleft palate and/or ankyloglossia; CLPA; CPX; dJ795G23.1; T-box 22; T-box protein 22; T-box transcription factor TBX22; TBXX
Mus musculus (house mouse) : Tbx22 (T-box 22)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tbx22 (T-box transcription factor 22)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbx22 (T-box transcription factor 22)
Pan paniscus (bonobo/pygmy chimpanzee) : TBX22 (T-box transcription factor 22)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbx22 (T-box transcription factor 22)
Sus scrofa (pig) : TBX22 (T-box transcription factor 22)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X80,014,753 - 80,031,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X79,270,255 - 79,287,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X79,156,911 - 79,173,924 (+)NCBINCBI36hg18NCBI36
Build 34X79,083,886 - 79,093,413NCBI
CeleraX79,510,188 - 79,527,202 (+)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX72,851,434 - 72,868,446 (+)NCBIHuRef
CHM1_1X79,163,473 - 79,180,486 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TBX22
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343120
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.