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Gene: MED14 (mediator complex subunit 14) Homo sapiens
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Symbol: MED14
Name: mediator complex subunit 14
Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activator-recruited cofactor 150 kDa component; ARC150; cofactor required for Sp1 transcriptional activation subunit 2; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD); CRSP complex subunit 2; CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; hRGR1; human homolog of yeast RGR1; mediator of RNA polymerase II transcription subunit 14; MGC104513; RGR1; RGR1 homolog; thyroid hormone receptor-associated protein complex 170 kDa component; thyroid hormone receptor-associated protein complex component TRAP170; transcriptional co-activator CRSP150; transcriptional coactivator CRSP150; TRAP170; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component
Orthologs:
Mus musculus (house mouse) : Med14 (mediator complex subunit 14)  MGI  Alliance
Rattus norvegicus (Norway rat) : Med14 (mediator complex subunit 14)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Med14 (mediator complex subunit 14)
Pan paniscus (bonobo/pygmy chimpanzee) : MED14 (mediator complex subunit 14)
Canis lupus familiaris (dog) : MED14 (mediator complex subunit 14)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Med14 (mediator complex subunit 14)
Sus scrofa (pig) : MED14 (mediator complex subunit 14)
more info ...
Related Pseudogenes: MED14P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X40,648,305 - 40,736,122 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X40,508,795 - 40,595,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X40,393,739 - 40,479,748 (-)NCBINCBI36hg18NCBI36
Build 34X40,263,811 - 40,351,037NCBI
CeleraX44,649,421 - 44,734,350 (-)NCBI
Cytogenetic MapXp11.4NCBI
HuRefX38,238,905 - 38,324,580 (-)NCBIHuRef
CHM1_1X40,540,939 - 40,626,911 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
 
More on MED14
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343127
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.