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Gene: PDK3 (pyruvate dehydrogenase kinase 3) Homo sapiens
Symbol: PDK3
Name: pyruvate dehydrogenase kinase 3
CRRD ID: 1343163
Description: Exhibits ATP binding activity; protein serine/threonine kinase activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including hypoxia-inducible factor-1alpha signaling pathway; peroxisome proliferator activated receptor signaling pathway; and regulation of acetyl-CoA biosynthetic process from pyruvate. Localizes to mitochondrion and nucleolus. Implicated in Charcot-Marie-Tooth disease X-linked dominant 6.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; CMTX6; GS1-358P8.4; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase kinase, isozyme 3; pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Mus musculus (house mouse) : Pdk3 (pyruvate dehydrogenase kinase, isoenzyme 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdk3 (pyruvate dehydrogenase kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdk3 (pyruvate dehydrogenase kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PDK3 (pyruvate dehydrogenase kinase 3)
Canis lupus familiaris (dog) : PDK3 (pyruvate dehydrogenase kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdk3 (pyruvate dehydrogenase kinase 3)
Sus scrofa (pig) : PDK3 (pyruvate dehydrogenase kinase 3)
Chlorocebus sabaeus (African green monkey) : PDK3 (pyruvate dehydrogenase kinase 3)
Heterocephalus glaber (naked mole-rat) : Pdk3 (pyruvate dehydrogenase kinase 3)
more info ...
Related Pseudogenes: AL121839.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX24,465,221 - 24,550,466 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX24,465,270 - 24,550,466 (+)EnsemblGRCh38hg38GRCh38
GRCh38X24,465,286 - 24,550,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,483,344 - 24,568,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,393,475 - 24,462,463 (+)NCBINCBI36hg18NCBI36
Build 34X24,243,210 - 24,312,199NCBI
CeleraX28,606,234 - 28,691,468 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX22,225,142 - 22,310,559 (+)NCBIHuRef
CHM1_1X24,514,817 - 24,600,156 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343163
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.