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Gene: PDK3 (pyruvate dehydrogenase kinase 3) Homo sapiens
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Symbol: PDK3
Name: pyruvate dehydrogenase kinase 3
Description: Exhibits ATP binding activity; protein serine/threonine kinase activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including hypoxia-inducible factor-1alpha signaling pathway; peroxisome proliferator activated receptor signaling pathway; and regulation of acetyl-CoA biosynthetic process from pyruvate. Localizes to the mitochondrion and nucleolus. Implicated in Charcot-Marie-Tooth disease X-linked dominant 6.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; CMTX6; GS1-358P8.4; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase kinase, isozyme 3; pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
Orthologs:
Mus musculus (house mouse) : Pdk3 (pyruvate dehydrogenase kinase, isoenzyme 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdk3 (pyruvate dehydrogenase kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdk3 (pyruvate dehydrogenase kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PDK3 (pyruvate dehydrogenase kinase 3)
Canis lupus familiaris (dog) : PDK3 (pyruvate dehydrogenase kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdk3 (pyruvate dehydrogenase kinase 3)
Sus scrofa (pig) : PDK3 (pyruvate dehydrogenase kinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X24,465,227 - 24,550,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,483,344 - 24,568,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,393,475 - 24,462,463 (+)NCBINCBI36hg18NCBI36
Build 34X24,243,210 - 24,312,199NCBI
CeleraX28,606,234 - 28,691,468 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX22,225,142 - 22,310,559 (+)NCBIHuRef
CHM1_1X24,514,817 - 24,600,156 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PDK3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343163
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.