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Gene: KLK3 (kallikrein related peptidase 3) Homo sapiens
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Symbol: KLK3
Name: kallikrein related peptidase 3
Description: Exhibits hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and serine-type endopeptidase activity. Involved in antibacterial peptide production and proteolysis. Localizes to extracellular space and protein-containing complex. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APS; gamma-seminoprotein; hK3; kallikrein 3, (prostate specific antigen); kallikrein-3; kallikrein-related peptidase 3; KLK2A1; P-30 antigen; prostate specific antigen; prostate-specific antigen; PSA; semenogelase; seminin
Orthologs:
Pan paniscus (bonobo/pygmy chimpanzee) : KLK3 (prostate-specific antigen)
Canis lupus familiaris (dog) : KLK2 (kallikrein-related peptidase 2)
Chlorocebus sabaeus (African green monkey) : KLK3 (kallikrein related peptidase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1950,854,915 - 50,860,764 (+)EnsemblGRCh38hg38GRCh38
GRCh381950,854,915 - 50,860,764 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371951,358,171 - 51,364,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,049,983 - 56,055,832 (+)NCBINCBI36hg18NCBI36
Build 341956,049,982 - 56,051,081NCBI
Celera1948,409,273 - 48,415,128 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,693,102 - 47,698,947 (+)NCBIHuRef
CHM1_11951,359,975 - 51,365,826 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KLK3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343198
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.