Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ARHGAP4 (Rho GTPase activating protein 4) Homo sapiens
Symbol: ARHGAP4
Name: Rho GTPase activating protein 4
Description: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C1; KIAA0131; p115; RGC1; rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; rho-type GTPase-activating protein 4; RhoGAP4; SrGAP4
Mus musculus (house mouse) : Arhgap4 (Rho GTPase activating protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arhgap4 (Rho GTPase activating protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgap4 (Rho GTPase activating protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ARHGAP4 (Rho GTPase activating protein 4)
Canis lupus familiaris (dog) : ARHGAP4 (Rho GTPase activating protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgap4 (Rho GTPase activating protein 4)
Sus scrofa (pig) : ARHGAP4 (Rho GTPase activating protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X153,907,376 - 153,926,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,172,830 - 153,191,777 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,826,025 - 152,844,892 (-)NCBINCBI36hg18NCBI36
Build 34X152,693,677 - 152,712,545NCBI
CeleraX153,406,543 - 153,425,434 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,824,230 - 141,844,372 (-)NCBIHuRef
CHM1_1X153,047,278 - 153,066,168 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ARHGAP4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343373
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.