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Gene: MIR34A (microRNA 34a) Homo sapiens
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Symbol: MIR34A
Name: microRNA 34a
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-34; mir-34a; MIRN34A; miRNA34A
Orthologs:
Mus musculus (house mouse) : Mir34a (microRNA 34a)  MGI
Rattus norvegicus (Norway rat) : Mir34a (microRNA 34a)  Alliance
Canis lupus familiaris (dog) : MIR34A (microRNA mir-34a)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,151,668 - 9,151,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3719,211,727 - 9,211,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,134,313 - 9,134,422 (-)NCBINCBI36hg18NCBI36
Celera18,321,161 - 8,321,270 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef18,362,551 - 8,362,660 (-)NCBIHuRef
CHM1_119,201,981 - 9,202,090 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Clinical Variants

Additional Information

External Database Links
 
More on MIR34A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343452
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.