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Gene: GUCY2D (guanylate cyclase 2D, retinal) Homo sapiens
Symbol: GUCY2D
Name: guanylate cyclase 2D, retinal
Description: Exhibits guanylate cyclase activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Localizes to endoplasmic reticulum membrane and photoreceptor outer segment. Implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CACD1; CG-E; cone rod dystrophy 5; cone rod dystrophy 6; CORD5; CORD6; CSNB1I; CYGD; guanylate cyclase 2D, membrane (retina-specific); GUC1A4; GUC2D; LCA; LCA1; RCD2; retGC; RETGC-1; retinal guanylate cyclase 1; retinal guanylyl cyclase 1; rod outer segment membrane guanylate cyclase; ROS-GC; ROS-GC1; ROSGC
Mus musculus (house mouse) : Gucy2e (guanylate cyclase 2e)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gucy2d (guanylate cyclase 2D, retinal)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gucy2d (guanylate cyclase 2D, retinal)
Pan paniscus (bonobo/pygmy chimpanzee) : GUCY2D (guanylate cyclase 2D, retinal)
Canis lupus familiaris (dog) : GUCY2D (guanylate cyclase 2D, retinal)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gucy2d (guanylate cyclase 2D, retinal)
Sus scrofa (pig) : GUCY2D (guanylate cyclase 2D, retinal)
Chlorocebus sabaeus (African green monkey) : GUCY2D (guanylate cyclase 2D, retinal)
Heterocephalus glaber (naked mole-rat) : Gucy2d (guanylate cyclase 2D, retinal)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl178,002,615 - 8,020,342 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl178,002,594 - 8,020,339 (+)EnsemblGRCh38hg38GRCh38
GRCh38178,002,615 - 8,020,342 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,905,988 - 7,923,658 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,846,713 - 7,864,382 (+)NCBINCBI36hg18NCBI36
Build 34177,846,716 - 7,864,382NCBI
Celera177,933,553 - 7,951,223 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,800,798 - 7,818,448 (+)NCBIHuRef
CHM1_1177,914,754 - 7,932,424 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GUCY2D
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343485
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.