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Gene: TNKS (tankyrase) Homo sapiens
Symbol: TNKS
Name: tankyrase
Description: Exhibits histone binding activity; transferase activity, transferring pentosyl groups; and zinc ion binding activity. Involved in several processes, including cellular protein modification process; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; and regulation of DNA metabolic process. Localizes to Golgi apparatus; mitotic spindle pole; and nucleus; PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; INTERACTS WITH 2-hydroxypropanoic acid; 3-isobutyl-1-methyl-7H-xanthine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ADP-ribosyltransferase diphtheria toxin-like 5; ARTD5; PARP-5a; PARP5A; PARPL; pART5; poly [ADP-ribose] polymerase 5A; poly [ADP-ribose] polymerase tankyrase-1; TANK1; tankyrase I; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; TIN1; TINF1; TNKS-1; TNKS1; TRF1-interacting ankyrin-related ADP-ribose polymerase; TRF1-interacting ankyrin-related ADP-ribose polymerase 1
Mus musculus (house mouse) : Tnks (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnks (tankyrase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnks (tankyrase)
Pan paniscus (bonobo/pygmy chimpanzee) : TNKS (tankyrase)
Canis lupus familiaris (dog) : TNKS (tankyrase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnks (tankyrase)
Sus scrofa (pig) : TNKS (tankyrase)
Chlorocebus sabaeus (African green monkey) : TNKS (tankyrase)
Heterocephalus glaber (naked mole-rat) : Tnks (tankyrase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl89,555,912 - 9,782,346 (+)EnsemblGRCh38hg38GRCh38
GRCh3889,555,230 - 9,782,346 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3789,412,756 - 9,639,856 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3689,450,855 - 9,677,266 (+)NCBINCBI36hg18NCBI36
Build 3489,450,854 - 9,671,801NCBI
Celera88,541,508 - 8,765,562 (+)NCBI
Cytogenetic Map8p23.1NCBI
HuRef88,339,612 - 8,568,337 (+)NCBIHuRef
CHM1_189,478,677 - 9,705,116 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNKS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343497
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.