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Gene: IL27 (interleukin 27) Homo sapiens
Symbol: IL27
Name: interleukin 27
Description: Predicted to have interleukin-27 receptor binding activity. Involved in positive regulation of interferon-gamma biosynthetic process and regulation of T-helper 1 cell differentiation. Predicted to localize to the extracellular space. Implicated in asthma and chronic obstructive pulmonary disease. Biomarker of asthma and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IL-27; IL-27 p28 subunit; IL-27 subunit alpha; IL-27-A; IL-27A; IL27-A; IL27A; IL27p28; IL30; interleukin 30; interleukin-27 subunit alpha; interleukin-30; MGC71873; p28
Mus musculus (house mouse) : Il27 (interleukin 27)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il27 (interleukin 27)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il27 (interleukin 27)
Pan paniscus (bonobo/pygmy chimpanzee) : IL27 (interleukin 27)
Canis lupus familiaris (dog) : IL27 (interleukin 27)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il27 (interleukin 27)
Sus scrofa (pig) : IL27 (interleukin 27)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1628,499,362 - 28,512,051 (-)Ensembl
GRCh381628,499,362 - 28,526,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371628,510,683 - 28,518,155 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,418,184 - 28,425,656 (-)NCBINCBI36hg18NCBI36
Build 341628,418,472 - 28,425,633NCBI
Celera1627,685,614 - 27,693,084 (+)NCBI
Cytogenetic Map16p12.1-p11.2NCBI
HuRef1626,536,601 - 26,544,073 (-)NCBIHuRef
CHM1_11629,522,293 - 29,529,765 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IL27
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343577
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.