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Gene: EPPK1 (epiplakin 1) Homo sapiens
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Symbol: EPPK1
Name: epiplakin 1
Description: Exhibits intermediate filament binding activity. Involved in several processes, including intermediate filament organization; negative regulation of epithelial cell proliferation; and negative regulation of wound healing. Localizes to several cellular components, including hemidesmosome; keratin filament; and perinucleolar compartment. Predicted to colocalize with intermediate filament.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 450 kDa epidermal antigen; epidermal autoantigen 450K; EPIPL; EPIPL1; epiplakin
Orthologs:
Mus musculus (house mouse) : Eppk1 (epiplakin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eppk1 (epiplakin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eppk1 (epiplakin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EPPK1 (epiplakin 1)
Canis lupus familiaris (dog) : EPPK1 (epiplakin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101961294 (epiplakin)
Sus scrofa (pig) : EPPK1 (epiplakin 1)
Chlorocebus sabaeus (African green monkey) : EPPK1 (epiplakin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl8143,857,324 - 143,878,467 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl8143,857,324 - 143,878,464 (-)EnsemblGRCh38hg38GRCh38
GRCh388143,857,319 - 143,879,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,939,492 - 144,952,632 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,012,206 - 145,019,422 (-)NCBINCBI36hg18NCBI36
Build 348145,011,899 - 145,019,422NCBI
Celera8141,252,725 - 141,261,566 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,192,173 - 140,206,900 (-)NCBIHuRef
CHM1_18144,979,743 - 144,992,882 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EPPK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343625
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.