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Gene: PTPN1 (protein tyrosine phosphatase non-receptor type 1) Homo sapiens
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Symbol: PTPN1
Name: protein tyrosine phosphatase non-receptor type 1
Description: Exhibits protein tyrosine phosphatase activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including actin cytoskeleton reorganization; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Localizes to several cellular components, including the cytoplasmic side of endoplasmic reticulum membrane; early endosome; and endoplasmic reticulum. Colocalizes with the plasma membrane. Implicated in type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: protein tyrosine phosphatase 1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP1B; tyrosine-protein phosphatase non-receptor type 1
Orthologs:
Mus musculus (house mouse) : Ptpn1 (protein tyrosine phosphatase, non-receptor type 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptpn1 (protein tyrosine phosphatase, non-receptor type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Canis lupus familiaris (dog) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
Sus scrofa (pig) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Chlorocebus sabaeus (African green monkey) : PTPN1 (protein tyrosine phosphatase non-receptor type 1)
Heterocephalus glaber (naked mole-rat) : Ptpn1 (protein tyrosine phosphatase non-receptor type 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2050,510,321 - 50,585,241 (+)Ensembl
GRCh382050,510,321 - 50,585,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372049,126,858 - 49,201,299 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,560,298 - 48,634,495 (+)NCBINCBI36hg18NCBI36
Build 342048,560,297 - 48,634,491NCBI
Celera2045,831,156 - 45,905,376 (+)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2045,875,585 - 45,950,061 (+)NCBIHuRef
CHM1_12049,031,996 - 49,106,433 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on PTPN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343639
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.