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Gene: MARCHF6 (membrane associated ring-CH-type finger 6) Homo sapiens
Symbol: MARCHF6
Name: membrane associated ring-CH-type finger 6
Description: Exhibits ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and ubiquitin-specific protease binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Localizes to the endoplasmic reticulum and integral component of endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DOA10; doa10 homolog; E3 ubiquitin-protein ligase MARCH6; FAME3; KIAA0597; MARCH-VI; MARCH6; membrane associated ring finger 6; membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase; membrane-associated RING finger protein 6; membrane-associated RING-CH finger protein 6; membrane-associated RING-CH protein VI; protein TEB-4; RING finger protein 176; RING-type E3 ubiquitin transferase MARCH6; RNF176; TEB4
Mus musculus (house mouse) : Marchf6 (membrane associated ring-CH-type finger 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Marchf6 (membrane associated ring-CH-type finger 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Marchf6 (membrane associated ring-CH-type finger 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MARCHF6 (membrane associated ring-CH-type finger 6)
Canis lupus familiaris (dog) : MARCHF6 (membrane associated ring-CH-type finger 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Marchf6 (membrane associated ring-CH-type finger 6)
Sus scrofa (pig) : MARCHF6 (membrane associated ring-CH-type finger 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl510,353,695 - 10,440,388 (+)Ensembl
GRCh38510,353,693 - 10,440,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37510,353,751 - 10,440,500 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36510,406,828 - 10,488,491 (+)NCBINCBI36hg18NCBI36
Build 34510,406,827 - 10,488,491NCBI
Celera510,391,947 - 10,473,622 (+)NCBI
Cytogenetic Map5p15.2NCBI
HuRef510,338,021 - 10,424,590 (+)NCBIHuRef
CHM1_1510,353,128 - 10,440,366 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MARCHF6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343716
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.