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Gene: GPX3 (glutathione peroxidase 3) Homo sapiens
Symbol: GPX3
Name: glutathione peroxidase 3
Description: Exhibits glutathione peroxidase activity and selenium binding activity. Involved in protein homotetramerization. Localizes to the extracellular space. Implicated in type 2 diabetes mellitus. Biomarker of nephrotic syndrome; type 1 diabetes mellitus; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: extracellular glutathione peroxidase; glutathione peroxidase 3 (plasma); GPx-3; GPx-P; GSHPx-3; GSHPx-P; plasma glutathione peroxidase
Mus musculus (house mouse) : Gpx3 (glutathione peroxidase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpx3 (glutathione peroxidase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpx3 (glutathione peroxidase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GPX3 (glutathione peroxidase 3)
Canis lupus familiaris (dog) : GPX3 (glutathione peroxidase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpx3 (glutathione peroxidase 3)
Sus scrofa (pig) : GPX3 (glutathione peroxidase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5151,020,438 - 151,028,992 (+)Ensembl
GRCh385151,020,591 - 151,028,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375150,399,999 - 150,408,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,380,192 - 150,388,747 (+)NCBINCBI36hg18NCBI36
Build 345150,380,111 - 150,388,741NCBI
Celera5146,481,339 - 146,489,894 (+)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5145,545,808 - 145,554,363 (+)NCBIHuRef
CHM1_15149,832,791 - 149,841,346 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GPX3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343858
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.