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Gene: PDHB (pyruvate dehydrogenase E1 subunit beta) Homo sapiens
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Symbol: PDHB
Name: pyruvate dehydrogenase E1 subunit beta
Description: Exhibits pyruvate dehydrogenase (acetyl-transferring) activity. Contributes to pyruvate dehydrogenase (NAD+) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Localizes to mitochondrion; nucleoplasm; and pyruvate dehydrogenase complex. Implicated in pyruvate decarboxylase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp564K0164; PDHBD; PDHE1-B; PDHE1B; PHE1B; pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 beta subunit; pyruvate dehydrogenase E1 component subunit beta, mitochondrial; pyruvate dehydrogenase, E1 beta polypeptide
Orthologs:
Mus musculus (house mouse) : Pdhb (pyruvate dehydrogenase (lipoamide) beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdhb (pyruvate dehydrogenase E1 subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdhb (pyruvate dehydrogenase E1 beta subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : PDHB (pyruvate dehydrogenase E1 beta subunit)
Canis lupus familiaris (dog) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdhb (pyruvate dehydrogenase E1 beta subunit)
Sus scrofa (pig) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Chlorocebus sabaeus (African green monkey) : PDHB (pyruvate dehydrogenase E1 subunit beta)
Heterocephalus glaber (naked mole-rat) : Pdhb (pyruvate dehydrogenase E1 subunit beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl358,427,630 - 58,433,857 (-)EnsemblGRCh38hg38GRCh38
GRCh38358,427,630 - 58,433,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37358,413,357 - 58,419,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,388,394 - 58,394,605 (-)NCBINCBI36hg18NCBI36
Build 34358,388,397 - 58,394,594NCBI
Celera358,427,174 - 58,433,398 (-)NCBI
Cytogenetic Map3p14.3NCBI
HuRef358,509,470 - 58,515,692 (-)NCBIHuRef
CHM1_1358,363,623 - 58,369,848 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PDHB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343920
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.