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Gene: ADAMTS5 (ADAM metallopeptidase with thrombospondin type 1 motif 5) Homo sapiens
Symbol: ADAMTS5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Description: Predicted to have integrin binding activity and metallopeptidase activity. Predicted to be involved in negative regulation of cold-induced thermogenesis. Predicted to localize to the endoplasmic reticulum lumen and extracellular matrix. Implicated in osteoarthritis. Biomarker of osteoarthritis and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: a disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADMP-2; aggrecanase-2; FLJ36738
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2126,917,922 - 26,967,088 (-)Ensembl
GRCh382126,917,922 - 26,967,758 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372128,290,231 - 28,339,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362127,212,112 - 27,260,703 (-)NCBINCBI36hg18NCBI36
Build 342127,215,656 - 27,260,703NCBI
Celera2113,473,563 - 13,522,743 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2113,695,092 - 13,744,202 (-)NCBIHuRef
CHM1_12127,852,147 - 27,901,362 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ADAMTS5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1343923
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.