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Gene: PON3 (paraoxonase 3) Homo sapiens
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Symbol: PON3
Name: paraoxonase 3
Description: Exhibits arylesterase activity and protein homodimerization activity. Involved in aromatic compound catabolic process and carboxylic acid catabolic process. Localizes to the extracellular exosome. Implicated in Alzheimer's disease; amyotrophic lateral sclerosis; and atherosclerosis. Biomarker of Crohn's disease; celiac disease; and ulcerative colitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: arylesterase 3; paraoxanase-3; serum paraoxonase/lactonase 3
Orthologs:
Mus musculus (house mouse) : Pon3 (paraoxonase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pon3 (paraoxonase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pon3 (paraoxonase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PON3 (paraoxonase 3)
Canis lupus familiaris (dog) : PON3 (paraoxonase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pon3 (paraoxonase 3)
Sus scrofa (pig) : PON3 (paraoxonase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,359,872 - 95,396,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37794,989,181 - 95,025,702 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,827,120 - 94,863,623 (-)NCBINCBI36hg18NCBI36
Build 34794,633,925 - 94,670,313NCBI
Celera789,687,888 - 89,724,394 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,596,240 - 89,632,745 (-)NCBIHuRef
CHM1_1794,919,217 - 94,955,721 (-)NCBICHM1_1
CRA_TCAGchr7v2794,318,186 - 94,354,692 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PON3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344009
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.