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Gene: IRF3 (interferon regulatory factor 3) Homo sapiens
Symbol: IRF3
Name: interferon regulatory factor 3
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in TRIF-dependent toll-like receptor signaling pathway; positive regulation of transcription by RNA polymerase II; and positive regulation of type I interferon production. Localizes to cytosol and nucleus. Implicated in brain disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IIAE7; IRF-3
Mus musculus (house mouse) : Irf3 (interferon regulatory factor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irf3 (interferon regulatory factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf3 (interferon regulatory factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF3 (interferon regulatory factor 3)
Canis lupus familiaris (dog) : IRF3 (interferon regulatory factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf3 (interferon regulatory factor 3)
Sus scrofa (pig) : IRF3 (interferon regulatory factor 3)
Chlorocebus sabaeus (African green monkey) : IRF3 (interferon regulatory factor 3)
Heterocephalus glaber (naked mole-rat) : Irf3 (interferon regulatory factor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1949,659,569 - 49,665,875 (-)EnsemblGRCh38hg38GRCh38
GRCh381949,659,569 - 49,665,875 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,162,826 - 50,169,132 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,854,641 - 54,860,936 (-)NCBINCBI36hg18NCBI36
Build 341954,854,641 - 54,860,926NCBI
Celera1947,032,161 - 47,038,466 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,539,596 - 46,545,904 (-)NCBIHuRef
CHM1_11950,164,615 - 50,170,921 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRF3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344104
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.