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Gene: PHF1 (PHD finger protein 1) Homo sapiens
Symbol: PHF1
Name: PHD finger protein 1
Description: Exhibits methylated histone binding activity. Involved in cellular response to DNA damage stimulus; negative regulation of histone H3-K27 methylation; and positive regulation of histone H3-K27 methylation. Localizes to nucleoplasm and site of double-strand break. Colocalizes with ESC/E(Z) complex and centrosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hPCl1; hPHF1; MTF2L2; PCL1; PHF2; polycomb-like 1; polycomb-like protein 1; TDRD19C; testicular tissue protein Li 140; tudor domain containing 19C
Mus musculus (house mouse) : Phf1 (PHD finger protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phf1 (PHD finger protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phf1 (PHD finger protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PHF1 (PHD finger protein 1)
Canis lupus familiaris (dog) : PHF1 (PHD finger protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phf1 (PHD finger protein 1)
Sus scrofa (pig) : PHF1 (PHD finger protein 1)
Chlorocebus sabaeus (African green monkey) : PHF1 (PHD finger protein 1)
Heterocephalus glaber (naked mole-rat) : Phf1 (PHD finger protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl633,410,399 - 33,416,453 (+)EnsemblGRCh38hg38GRCh38
GRCh38633,410,751 - 33,416,443 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37633,378,773 - 33,384,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,486,772 - 33,492,194 (+)NCBINCBI36hg18NCBI36
Build 34633,486,771 - 33,492,194NCBI
Celera634,933,196 - 34,938,653 (+)NCBI
Cytogenetic Map6p21.32NCBI
HuRef633,120,927 - 33,126,379 (+)NCBIHuRef
CHM1_1633,380,668 - 33,386,125 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PHF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344150
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.