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Gene: OPA1 (OPA1 mitochondrial dynamin like GTPase) Homo sapiens
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Symbol: OPA1
Name: OPA1 mitochondrial dynamin like GTPase
Description: Exhibits GTPase activity; cardiolipin binding activity; and phosphatidic acid binding activity. Involved in several processes, including GTP metabolic process; mitochondrial fusion; and negative regulation of apoptotic signaling pathway. Localizes to the cytosol; mitochondrial envelope; and nucleoplasm. Implicated in dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; and optic atrophy. Biomarker of Alzheimer's disease; congestive heart failure; primary open angle glaucoma; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BERHS; dynamin-like 120 kDa protein, mitochondrial; dynamin-like guanosine triphosphatase; FLJ12460; KIAA0567; largeG; MGM1; mitochondrial dynamin-like 120 kDa protein; mitochondrial dynamin-like GTPase; MTDPS14; NPG; NTG; OPA1, mitochondrial dynamin like GTPase; optic atrophy 1 (autosomal dominant); optic atrophy protein 1
Orthologs:
Mus musculus (house mouse) : Opa1 (OPA1, mitochondrial dynamin like GTPase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Opa1 (OPA1, mitochondrial dynamin like GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Canis lupus familiaris (dog) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Opa1 (OPA1 mitochondrial dynamin like GTPase)
Sus scrofa (pig) : OPA1 (OPA1 mitochondrial dynamin like GTPase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383193,593,144 - 193,697,811 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373193,310,933 - 193,415,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363194,793,806 - 194,898,009 (+)NCBINCBI36hg18NCBI36
Build 343194,793,813 - 194,898,017NCBI
Celera3191,726,124 - 191,830,778 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3190,698,074 - 190,803,338 (+)NCBIHuRef
CHM1_13193,273,732 - 193,378,486 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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