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Gene: NCOA3 (nuclear receptor coactivator 3) Homo sapiens
Symbol: NCOA3
Name: nuclear receptor coactivator 3
Description: Exhibits several functions, including disordered domain specific binding activity; protein N-terminus binding activity; and transcription coactivator activity. Involved in cellular response to estradiol stimulus; positive regulation of keratinocyte differentiation; and positive regulation of transcription by RNA polymerase II. Localizes to cytosol; nuclear lumen; and protein-containing complex. Implicated in obesity. Biomarker of breast carcinoma and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACTR; AIB-1; AIB1; amplified in breast cancer 1 protein; bHLHe42; CAGH16; CBP-interacting protein; class E basic helix-loop-helix protein 42; CTG26; KAT13B; MGC141848; pCIP; RAC3; receptor-associated coactivator 3; SRC-3; SRC3; steroid receptor coactivator protein 3; thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1
Mus musculus (house mouse) : Ncoa3 (nuclear receptor coactivator 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ncoa3 (nuclear receptor coactivator 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncoa3 (nuclear receptor coactivator 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NCOA3 (nuclear receptor coactivator 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncoa3 (nuclear receptor coactivator 3)
Sus scrofa (pig) : NCOA3 (nuclear receptor coactivator 3)
Chlorocebus sabaeus (African green monkey) : NCOA3 (nuclear receptor coactivator 3)
Heterocephalus glaber (naked mole-rat) : Ncoa3 (nuclear receptor coactivator 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: RAC3 (Gene ID: 5881) and NCOA3 (Gene ID: 8202) share the RAC3 symbol/alias in common. RAC3 is a widely used alternative name for nuclear receptor coactivator 3 (NCOA3), which can be confused with the official symbol for ras-related C3 botulinum toxin substrate 3 (RAC3). [06 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2047,501,887 - 47,656,877 (+)EnsemblGRCh38hg38GRCh38
GRCh382047,501,887 - 47,656,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372046,130,601 - 46,285,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362045,564,064 - 45,719,023 (+)NCBINCBI36hg18NCBI36
Build 342045,564,063 - 45,719,019NCBI
Celera2042,844,227 - 42,999,274 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2042,872,332 - 43,026,949 (+)NCBIHuRef
CHM1_12046,033,477 - 46,188,916 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NCOA3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344181
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.