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Gene: TNF (tumor necrosis factor) Homo sapiens
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Symbol: TNF
Name: tumor necrosis factor
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APC1 protein; cachectin; DIF; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; TNF-a; TNF-alpha; TNFA; TNFSF2; TNLG1F; tumor necrosis factor alpha; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
Orthologs:
Mus musculus (house mouse) : Tnf (tumor necrosis factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnf (tumor necrosis factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnf (tumor necrosis factor)
Pan paniscus (bonobo/pygmy chimpanzee) : TNF (tumor necrosis factor)
Canis lupus familiaris (dog) : TNF (tumor necrosis factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnf (tumor necrosis factor)
Sus scrofa (pig) : TNF (tumor necrosis factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,575,565 - 31,578,336 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,543,344 - 31,546,113 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,651,329 - 31,654,091 (+)NCBINCBI36hg18NCBI36
Build 34631,651,328 - 31,654,091NCBI
Celera633,141,565 - 33,144,327 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,330,078 - 31,332,847 (+)NCBIHuRef
CHM1_1631,545,476 - 31,548,245 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model