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Gene: BRCC3 (BRCA1/BRCA2-containing complex subunit 3) Homo sapiens
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Symbol: BRCC3
Name: BRCA1/BRCA2-containing complex subunit 3
Description: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCC36; BRISC complex subunit BRCC36; C6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36; RP11-143H17.2
Orthologs:
Mus musculus (house mouse) : Brcc3 (BRCA1/BRCA2-containing complex, subunit 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Brcc3 (BRCA1/BRCA2-containing complex, subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brcc3 (BRCA1/BRCA2-containing complex subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
Canis lupus familiaris (dog) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brcc3 (BRCA1/BRCA2-containing complex subunit 3)
Sus scrofa (pig) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
more info ...
Related Pseudogenes: BRCC3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,071,403 - 155,126,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X154,299,695 - 154,351,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,952,904 - 154,004,543 (+)NCBINCBI36hg18NCBI36
Build 34X153,863,504 - 153,915,052NCBI
CeleraX154,458,427 - 154,510,104 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,845,949 - 142,896,583 (+)NCBIHuRef
CHM1_1X154,211,322 - 154,263,032 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BRCC3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344323
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.