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Gene: BRCC3 (BRCA1/BRCA2-containing complex subunit 3) Homo sapiens
Symbol: BRCC3
Name: BRCA1/BRCA2-containing complex subunit 3
Description: Exhibits enzyme regulator activity; peptidase activity, acting on L-amino acid peptides; and polyubiquitin modification-dependent protein binding activity. Involved in several processes, including histone H2A K63-linked deubiquitination; response to X-ray; and signal transduction involved in G2 DNA damage checkpoint. Localizes to cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCC36; BRISC complex subunit BRCC36; C6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36; RP11-143H17.2
Mus musculus (house mouse) : Brcc3 (BRCA1/BRCA2-containing complex, subunit 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Brcc3 (BRCA1/BRCA2-containing complex, subunit 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brcc3 (BRCA1/BRCA2-containing complex subunit 3)
Pan paniscus (bonobo/pygmy chimpanzee) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
Canis lupus familiaris (dog) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brcc3 (BRCA1/BRCA2-containing complex subunit 3)
Sus scrofa (pig) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
Chlorocebus sabaeus (African green monkey) : BRCC3 (BRCA1/BRCA2-containing complex subunit 3)
Heterocephalus glaber (naked mole-rat) : Brcc3 (BRCA1/BRCA2-containing complex subunit 3)
more info ...
Related Pseudogenes: BRCC3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX155,071,420 - 155,123,074 (+)EnsemblGRCh38hg38GRCh38
GRCh38X155,071,403 - 155,126,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X154,299,695 - 154,351,349 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,952,904 - 154,004,543 (+)NCBINCBI36hg18NCBI36
Build 34X153,863,504 - 153,915,052NCBI
CeleraX154,458,427 - 154,510,104 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,845,949 - 142,896,583 (+)NCBIHuRef
CHM1_1X154,211,322 - 154,263,032 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BRCC3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344323
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.