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Gene: ZFX (zinc finger protein X-linked) Homo sapiens
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Symbol: ZFX
Name: zinc finger protein X-linked
Description: This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: X-linked zinc finger protein; zinc finger protein, X-linked; zinc finger X-chromosomal protein; ZNF926
Orthologs:
Mus musculus (house mouse) : Zfx (zinc finger protein X-linked)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zfx (zinc finger protein X-linked)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zfx (zinc finger protein X-linked)
Pan paniscus (bonobo/pygmy chimpanzee) : ZFX (zinc finger protein, X-linked)
Canis lupus familiaris (dog) : ZFX (zinc finger protein X-linked)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zfx (zinc finger protein X-linked)
Sus scrofa (pig) : ZFX (zinc finger protein X-linked)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X24,148,989 - 24,216,255 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,167,047 - 24,234,372 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,077,824 - 24,142,549 (+)NCBINCBI36hg18NCBI36
Build 34X23,929,464 - 23,989,474NCBI
CeleraX28,291,063 - 28,357,675 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX21,911,587 - 21,977,093 (+)NCBIHuRef
CHM1_1X24,199,109 - 24,265,719 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ZFX
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344344
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.