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Gene: MYCN (MYCN proto-oncogene, bHLH transcription factor) Homo sapiens
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Symbol: MYCN
Name: MYCN proto-oncogene, bHLH transcription factor
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of gene expression and positive regulation of transcription by RNA polymerase II. Localizes to nucleolus and nucleoplasm. Implicated in Feingold syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe37; class E basic helix-loop-helix protein 37; MODED; MYCNOT; N-myc; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; ODED; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
Orthologs:
Mus musculus (house mouse) : Mycn (v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mycn (MYCN proto-oncogene, bHLH transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mycn (MYCN proto-oncogene, bHLH transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Canis lupus familiaris (dog) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mycn (MYCN proto-oncogene, bHLH transcription factor)
Sus scrofa (pig) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Chlorocebus sabaeus (African green monkey) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Heterocephalus glaber (naked mole-rat) : Mycn (MYCN proto-oncogene, bHLH transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl215,940,550 - 15,947,007 (+)EnsemblGRCh38hg38GRCh38
GRCh38215,940,550 - 15,947,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37216,080,683 - 16,087,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36215,998,134 - 16,004,580 (+)NCBINCBI36hg18NCBI36
Build 34216,032,643 - 16,037,721NCBI
Celera215,998,381 - 16,004,827 (+)NCBI
Cytogenetic Map2p24.3NCBI
HuRef215,934,021 - 15,938,396 (+)NCBIHuRef
CHM1_1216,010,346 - 16,016,915 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MYCN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344499
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.