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Gene: IL1RN (interleukin 1 receptor antagonist) Homo sapiens
Symbol: IL1RN
Name: interleukin 1 receptor antagonist
Description: Exhibits cytokine receptor binding activity. Involved in several processes, including acute-phase response; negative regulation of heterotypic cell-cell adhesion; and negative regulation of interleukin-1-mediated signaling pathway. Localizes to extracellular space. Implicated in several diseases, including autoimmune hypersensitivity disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Biomarker of several diseases, including chronic kidney disease (multiple); glomerulonephritis (multiple); lung disease (multiple); myositis (multiple); and obesity (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DIRA; ICIL-1RA; IL-1ra; IL-1ra3; IL-1RN; IL1 inhibitor; IL1F3; IL1RA; IL1RN (IL1F3); interleukin-1 receptor antagonist protein; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); IRAP; MGC10430; MVCD4; type II interleukin-1 receptor antagonist
Mus musculus (house mouse) : Il1rn (interleukin 1 receptor antagonist)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il1rn (interleukin 1 receptor antagonist)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1rn (interleukin 1 receptor antagonist)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1RN (interleukin 1 receptor antagonist)
Canis lupus familiaris (dog) : IL1RN (interleukin 1 receptor antagonist)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1rn (interleukin 1 receptor antagonist)
Sus scrofa (pig) : IL1RN (interleukin 1 receptor antagonist)
Chlorocebus sabaeus (African green monkey) : IL1RN (interleukin 1 receptor antagonist)
Heterocephalus glaber (naked mole-rat) : Il1rn (interleukin 1 receptor antagonist)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2113,107,214 - 113,134,016 (+)EnsemblGRCh38hg38GRCh38
GRCh382113,099,365 - 113,134,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,868,693 - 113,891,593 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,591,941 - 113,608,064 (+)NCBINCBI36hg18NCBI36
Build 342113,591,700 - 113,607,823NCBI
Celera2107,260,159 - 107,276,191 (+)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,329,950 - 106,345,897 (+)NCBIHuRef
CHM1_12113,879,899 - 113,896,017 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IL1RN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344540
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.