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Gene: PRKACA (protein kinase cAMP-activated catalytic subunit alpha) Homo sapiens
Symbol: PRKACA
Name: protein kinase cAMP-activated catalytic subunit alpha
Description: Exhibits enzyme binding activity; protein kinase A regulatory subunit binding activity; and protein kinase activity. Involved in several processes, including cellular response to glucose stimulus; regulation of bicellular tight junction assembly; and regulation of osteoblast differentiation. Localizes to several cellular components, including the cAMP-dependent protein kinase complex; nucleotide-activated protein kinase complex; and sperm midpiece. Colocalizes with the axoneme. Implicated in adrenal cortical adenoma; congestive heart failure; hypertrophic cardiomyopathy; and primary pigmented nodular adrenocortical disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC102831; MGC48865; PKA C-alpha; PKACA; PPNAD4; protein kinase A catalytic subunit
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1914,091,688 - 14,118,084 (-)Ensembl
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKACA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344608
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.