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Gene: ICOS (inducible T cell costimulator) Homo sapiens
Symbol: ICOS
Name: inducible T cell costimulator
CRRD ID: 1344621
Description: Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to localize to plasma membrane. Implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CVID1; inducible costimulator; inducible T-cell co-stimulator; inducible T-cell costimulator; MGC39850
Mus musculus (house mouse) : Icos (inducible T cell co-stimulator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Icos (inducible T-cell co-stimulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Icos (inducible T cell costimulator)
Pan paniscus (bonobo/pygmy chimpanzee) : ICOS (inducible T cell costimulator)
Canis lupus familiaris (dog) : ICOS (inducible T cell costimulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Icos (inducible T cell costimulator)
Sus scrofa (pig) : ICOS (inducible T cell costimulator)
Chlorocebus sabaeus (African green monkey) : ICOS (inducible T cell costimulator)
Heterocephalus glaber (naked mole-rat) : Icos (inducible T cell costimulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2203,936,763 - 203,961,577 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2203,936,748 - 203,961,577 (+)EnsemblGRCh38hg38GRCh38
GRCh382203,936,763 - 203,961,577 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372204,801,454 - 204,826,302 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362204,509,748 - 204,534,545 (+)NCBINCBI36hg18NCBI36
Build 342204,627,008 - 204,651,802NCBI
Celera2198,556,278 - 198,581,105 (+)NCBI
Cytogenetic Map2q33.2NCBI
HuRef2196,648,626 - 196,673,332 (+)NCBIHuRef
CHM1_12204,807,968 - 204,832,793 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ICOS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344621
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.