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Gene: NOD1 (nucleotide binding oligomerization domain containing 1) Homo sapiens
Symbol: NOD1
Name: nucleotide binding oligomerization domain containing 1
CRRD ID: 1344653
Description: Exhibits CARD domain binding activity; pattern recognition receptor activity; and protein homodimerization activity. Involved in several processes, including cellular response to muramyl dipeptide; positive regulation of intracellular signal transduction; and response to bacterium. Localizes to anchored component of plasma membrane; basolateral plasma membrane; and cytosol. Implicated in asthma. Biomarker of rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CARD4; caspase recruitment domain family, member 4; caspase recruitment domain-containing protein 4; CLR7.1; NLR family, CARD domain containing 1; NLRC1; nucleotide-binding oligomerization domain containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; nucleotide-binding oligomerization domain-containing protein 1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl730,424,527 - 30,478,784 (-)EnsemblGRCh38hg38GRCh38
GRCh38730,424,527 - 30,478,840 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,464,143 - 30,518,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,430,675 - 30,484,790 (-)NCBINCBI36hg18NCBI36
Build 34730,237,389 - 30,291,505NCBI
Celera730,453,464 - 30,507,713 (-)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,346,423 - 30,400,669 (-)NCBIHuRef
CHM1_1730,464,171 - 30,518,245 (-)NCBICHM1_1
CRA_TCAGchr7v2730,513,913 - 30,568,158 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NOD1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344653
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.