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Gene: AMOT (angiomotin) Homo sapiens
Symbol: AMOT
Name: angiomotin
Description: This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: angiomotin p130 isoform; angiomotin p80 isoform; KIAA1071
Mus musculus (house mouse) : Amot (angiomotin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Amot (angiomotin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Amot (angiomotin)
Pan paniscus (bonobo/pygmy chimpanzee) : AMOT (angiomotin)
Canis lupus familiaris (dog) : AMOT (angiomotin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Amot (angiomotin)
Sus scrofa (pig) : AMOT (angiomotin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X112,774,877 - 112,840,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X112,018,105 - 112,084,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X111,904,761 - 111,970,699 (-)NCBINCBI36hg18NCBI36
Build 34X111,823,875 - 111,890,188NCBI
CeleraX112,502,736 - 112,568,672 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX101,645,090 - 101,710,229 (-)NCBIHuRef
CHM1_1X111,929,234 - 111,995,169 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on AMOT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344662
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.