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Gene: LDOC1 (LDOC1 regulator of NFKB signaling) Homo sapiens
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Symbol: LDOC1
Name: LDOC1 regulator of NFKB signaling
Description: The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BCUR1; breast cancer, up-regulated 1; LDOC1, regulator of NFKB signaling; leucine zipper down-regulated in cancer 1; leucine zipper downregulated in cancer; leucine zipper protein down-regulated in cancer cells; leucine zipper, down-regulated in cancer 1; mammalian retrotransposon-derived 7; Mar7; Mart7; retrotransposon Gag like 7; RTL7; SIRH7; Sushi-Ichi retrotransposon homolog 7
Orthologs:
Mus musculus (house mouse) : Ldoc1 (regulator of NFKB signaling)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ldoc1 (LDOC1, regulator of NFKB signaling)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ldoc1 (LDOC1 regulator of NFKB signaling)
Pan paniscus (bonobo/pygmy chimpanzee) : LDOC1 (LDOC1 regulator of NFKB signaling)
Canis lupus familiaris (dog) : LDOC1 (LDOC1 regulator of NFKB signaling)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ldoc1 (LDOC1 regulator of NFKB signaling)
Sus scrofa (pig) : LDOC1 (LDOC1 regulator of NFKB signaling)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X141,175,745 - 141,177,214 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X140,269,930 - 140,271,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X140,097,596 - 140,098,976 (-)NCBINCBI36hg18NCBI36
Build 34X139,995,452 - 139,996,830NCBI
CeleraX140,808,897 - 140,810,277 (+)NCBI
Cytogenetic MapXq27.1NCBI
HuRefX129,731,182 - 129,732,563 (-)NCBIHuRef
CHM1_1X140,181,056 - 140,182,525 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LDOC1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344664
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.