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Gene: MIR146A (microRNA 146a) Homo sapiens
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Symbol: MIR146A
Name: microRNA 146a
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: microrna 146; miR-146a; MIRN146; MIRN146A; miRNA146A
Orthologs:
Mus musculus (house mouse) : Mir146 (microRNA 146)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mir146a (microRNA 146a)  Alliance
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,485,352 - 160,485,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375159,912,359 - 159,912,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,844,936 - 159,845,034 (+)NCBINCBI36hg18NCBI36
Celera5155,944,832 - 155,944,930 (+)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5155,005,782 - 155,005,880 (+)NCBIHuRef
CHM1_15159,345,261 - 159,345,359 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Sequence

Nucleotide Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on MIR146A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344673
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.