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Gene: DENND10 (DENN domain containing 10) Homo sapiens
Symbol: DENND10
Name: DENN domain containing 10
Description: Exhibits guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Localizes to cell and late endosome; INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; 4,4'-sulfonyldiphenol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DENN domain-containing protein 10; FAM45A; family with sequence similarity 45 member A; family with sequence similarity 45, member A; hypothetical protein LOC404636
Mus musculus (house mouse) : Dennd10 (DENN domain containing 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dennd10 (DENN domain containing 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dennd10 (DENN domain containing 10)
Pan paniscus (bonobo/pygmy chimpanzee) : DENND10 (DENN domain containing 10)
Canis lupus familiaris (dog) : DENND10 (DENN domain containing 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dennd10 (DENN domain containing 10)
Sus scrofa (pig) : DENND10 (DENN domain containing 10)
Chlorocebus sabaeus (African green monkey) : DENND10 (DENN domain containing 10)
Heterocephalus glaber (naked mole-rat) : Dennd10 (DENN domain containing 10)
more info ...
Related Pseudogenes: DENND10P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10119,104,086 - 119,137,984 (+)EnsemblGRCh38hg38GRCh38
GRCh3810119,104,082 - 119,137,984 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710120,863,594 - 120,897,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,853,601 - 120,887,213 (+)NCBINCBI36hg18NCBI36
Build 3410120,853,600 - 120,887,212NCBI
Celera10114,594,076 - 114,626,795 (+)NCBI
Cytogenetic Map10q26.11NCBI
HuRef10114,500,242 - 114,526,453 (+)NCBIHuRef
CHM1_110121,148,002 - 121,181,876 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DENND10
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344685
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.