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Gene: ACSL4 (acyl-CoA synthetase long chain family member 4) Homo sapiens
Symbol: ACSL4
Name: acyl-CoA synthetase long chain family member 4
Description: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACS4; acyl-CoA synthetase 4; acyl-CoA synthetase long-chain family member 4; FACL4; fatty-acid-Coenzyme A ligase, long-chain 4; LACS 4; LACS4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; long-chain-fatty-acid--CoA ligase 4; mental retardation, X-linked 63; mental retardation, X-linked 68; MRX63; MRX68
Mus musculus (house mouse) : Acsl4 (acyl-CoA synthetase long-chain family member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acsl4 (acyl-CoA synthetase long-chain family member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Canis lupus familiaris (dog) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Sus scrofa (pig) : ACSL4 (acyl-CoA synthetase long chain family member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X109,641,330 - 109,733,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X108,884,564 - 108,976,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X108,771,220 - 108,863,277 (-)NCBINCBI36hg18NCBI36
Build 34X108,690,710 - 108,782,764NCBI
CeleraX109,364,202 - 109,456,256 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX98,507,227 - 98,598,360 (-)NCBIHuRef
CHM1_1X108,795,825 - 108,887,899 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACSL4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344693
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.