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Gene: SOX2 (SRY-box transcription factor 2) Homo sapiens
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Symbol: SOX2
Name: SRY-box transcription factor 2
Description: Exhibits DNA-binding transcription factor activity and nucleic acid binding activity. Involved in several processes, including endodermal cell fate specification; positive regulation of macromolecule metabolic process; and sensory organ development. Localizes to the cytosol and nucleoplasm. Implicated in breast cancer; microphthalmia; and nasal cavity cancer. Biomarker of breast cancer; melanoma; squamous cell carcinoma; tongue squamous cell carcinoma; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ANOP3; MCOPS3; MGC2413; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY-box 2; SRY-related HMG-box gene 2; transcription factor SOX-2; transcription factor SOX2
Orthologs:
Mus musculus (house mouse) : Sox2 (SRY (sex determining region Y)-box 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sox2 (SRY-box transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sox2 (SRY-box transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SOX2 (SRY-box transcription factor 2)
Canis lupus familiaris (dog) : SOX2 (SRY-box transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sox2 (SRY-box transcription factor 2)
Sus scrofa (pig) : SOX2 (SRY-box transcription factor 2)
Chlorocebus sabaeus (African green monkey) : SOX2 (SRY-box transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Sox2 (SRY-box transcription factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3181,711,925 - 181,714,436 (+)Ensembl
GRCh383181,711,925 - 181,714,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373181,429,712 - 181,432,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363182,912,416 - 182,914,918 (+)NCBINCBI36hg18NCBI36
Build 343182,912,423 - 182,914,923NCBI
Celera3179,863,407 - 179,865,909 (+)NCBI
Cytogenetic Map3q26.33NCBI
HuRef3178,834,536 - 178,837,048 (+)NCBIHuRef
CHM1_13181,392,587 - 181,395,099 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SOX2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344695
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.