Gene: HYAL3 (hyaluronidase 3) Homo sapiens
Symbol: HYAL3
Name: hyaluronidase 3
Description: This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HYAL-3; hyaluronidase-3; hyaluronoglucosaminidase 3; hyaluronoglucosaminidase-3; LUCA-3; LUCA14; LUCA3; lung carcinoma protein 3; Minna14
Mus musculus (house mouse) : Hyal3 (hyaluronoglucosaminidase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hyal3 (hyaluronidase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hyal3 (hyaluronidase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : HYAL3 (hyaluronidase 3)
Canis lupus familiaris (dog) : HYAL3 (hyaluronidase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hyal3 (hyaluronidase 3)
Sus scrofa (pig) : HYAL3 (hyaluronidase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38350,292,828 - 50,299,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,330,259 - 50,336,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,305,266 - 50,311,903 (-)NCBINCBI36hg18NCBI36
Build 34350,305,265 - 50,311,903NCBI
Celera350,303,093 - 50,309,730 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,386,002 - 50,392,642 (-)NCBIHuRef
CHM1_1350,282,565 - 50,289,205 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HYAL3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344724
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-04-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.