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Gene: L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1) Homo sapiens
Symbol: L3MBTL1
Name: L3MBTL histone methyl-lysine binding protein 1
Description: Exhibits SAM domain binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; regulation of megakaryocyte differentiation; and regulation of mitotic nuclear division. Localizes to chromosome; nucleoplasm; and plasma membrane. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dJ138B7.3; DKFZp586P1522; FLJ41181; H-L(3)MBT; KIAA0681; l(3)mbt protein homolog; l(3)mbt-like 1; l(3)mbt-like 1 (Drosophila); L3MBTL; lethal (3) malignant brain tumor l(3); lethal(3)malignant brain tumor-like protein; lethal(3)malignant brain tumor-like protein 1; ZC2HC3
Mus musculus (house mouse) : L3mbtl1 (L3MBTL1 histone methyl-lysine binding protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : L3mbtl1 (L3MBTL histone methyl-lysine binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : L3mbtl1 (L3MBTL histone methyl-lysine binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1)
Canis lupus familiaris (dog) : L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : L3mbtl1 (L3MBTL histone methyl-lysine binding protein 1)
Sus scrofa (pig) : L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1)
Chlorocebus sabaeus (African green monkey) : L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1)
Heterocephalus glaber (naked mole-rat) : L3mbtl1 (L3MBTL histone methyl-lysine binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2043,489,442 - 43,550,950 (+)EnsemblGRCh38hg38GRCh38
GRCh382043,507,697 - 43,550,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372042,136,320 - 42,179,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,576,467 - 41,603,949 (+)NCBINCBI36hg18NCBI36
Build 342041,576,487 - 41,603,242NCBI
Celera2038,850,523 - 38,878,002 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2038,872,453 - 38,906,163 (+)NCBIHuRef
CHM1_12042,040,166 - 42,074,338 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on L3MBTL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344736
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.