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Gene: LAG3 (lymphocyte activating 3) Homo sapiens
Symbol: LAG3
Name: lymphocyte activating 3
Description: Exhibits MHC class II protein binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to localize to the extracellular region.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD223; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3
Mus musculus (house mouse) : Lag3 (lymphocyte-activation gene 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lag3 (lymphocyte activating 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lag3 (lymphocyte activating 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LAG3 (lymphocyte activating 3)
Canis lupus familiaris (dog) : LAG3 (lymphocyte activating 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lag3 (lymphocyte activating 3)
Sus scrofa (pig) : LAG3 (lymphocyte activating 3)
Chlorocebus sabaeus (African green monkey) : LAG3 (lymphocyte activating 3)
Heterocephalus glaber (naked mole-rat) : Lag3 (lymphocyte activating 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl126,772,512 - 6,778,455 (+)Ensembl
GRCh38126,772,483 - 6,778,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37126,881,670 - 6,887,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,751,931 - 6,757,880 (+)NCBINCBI36hg18NCBI36
Build 34126,751,930 - 6,757,880NCBI
Celera128,498,967 - 8,504,918 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef126,735,007 - 6,740,958 (+)NCBIHuRef
CHM1_1126,880,658 - 6,886,609 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LAG3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344873
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.