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Gene: LCK (LCK proto-oncogene, Src family tyrosine kinase) Homo sapiens
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Symbol: LCK
Name: LCK proto-oncogene, Src family tyrosine kinase
Description: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IMD22; leukocyte C-terminal Src kinase; LSK; lymphocyte cell-specific protein-tyrosine kinase; lymphocyte-specific protein tyrosine kinase; p56(LSTRA) protein-tyrosine kinase; p56lck; pp58lck; proto-oncogene tyrosine-protein kinase LCK; t cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; tyrosine-protein kinase Lck; YT16
Orthologs:
Mus musculus (house mouse) : Lck (lymphocyte protein tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lck (LCK proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,251,239 - 32,286,167 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,716,840 - 32,751,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,489,427 - 32,524,353 (+)NCBINCBI36hg18NCBI36
Build 34132,386,024 - 32,420,854NCBI
Celera130,987,010 - 31,022,233 (+)NCBI
Cytogenetic Map1p35.2NCBI
HuRef130,833,080 - 30,867,241 (+)NCBIHuRef
CHM1_1132,832,435 - 32,867,213 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LCK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344945
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.