Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: EDN3 (endothelin 3) Homo sapiens
Analyze
Symbol: EDN3
Name: endothelin 3
Description: Exhibits endothelin B receptor binding activity and hormone activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cell communication; and vein smooth muscle contraction. Localizes to the extracellular space. Implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; Waardenburg's syndrome; and congenital central hypoventilation syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endothelin-3; ET-3; ET3; HSCR4; MGC15067; MGC61498; PPET3; preproendothelin-3; truncated endothelin 3; WS4B
Orthologs:
Mus musculus (house mouse) : Edn3 (endothelin 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Edn3 (endothelin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn3 (endothelin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN3 (endothelin 3)
Canis lupus familiaris (dog) : EDN3 (endothelin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn3 (endothelin 3)
Sus scrofa (pig) : EDN3 (endothelin 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382059,300,415 - 59,325,992 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372057,875,499 - 57,901,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362057,308,894 - 57,334,442 (+)NCBINCBI36hg18NCBI36
Build 342057,308,893 - 57,334,441NCBI
Celera2054,616,141 - 54,641,690 (+)NCBI
Cytogenetic Map20q13.32NCBI
HuRef2054,662,632 - 54,688,190 (+)NCBIHuRef
CHM1_12057,776,813 - 57,802,379 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EDN3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344952
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.