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Gene: NELFE (negative elongation factor complex member E) Homo sapiens
Symbol: NELFE
Name: negative elongation factor complex member E
Description: The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D6S45; major histocompatibility complex gene RD; negative elongation factor E; negative elongation factor polypeptide E; NELF-E; nuclear protein; RD; RD RNA binding protein; RD RNA-binding protein; RDBP; RDP; RNA-binding protein RD
Mus musculus (house mouse) : Nelfe (negative elongation factor complex member E, Rdbp)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nelfe (negative elongation factor complex member E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nelfe (negative elongation factor complex member E)
Pan paniscus (bonobo/pygmy chimpanzee) : NELFE (negative elongation factor complex member E)
Canis lupus familiaris (dog) : NELFE (negative elongation factor complex member E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nelfe (negative elongation factor complex member E)
Sus scrofa (pig) : NELFE (negative elongation factor complex member E)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38631,952,087 - 31,959,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,919,864 - 31,926,864 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,027,843 - 32,034,843 (-)NCBINCBI36hg18NCBI36
Build 34632,027,843 - 32,034,747NCBI
Celera633,519,627 - 33,526,530 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,706,833 - 31,713,834 (-)NCBIHuRef
CHM1_1631,921,945 - 31,928,945 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NELFE
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344973
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.