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Gene: NELFE (negative elongation factor complex member E) Homo sapiens
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Symbol: NELFE
Name: negative elongation factor complex member E
Description: The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D6S45; major histocompatibility complex gene RD; negative elongation factor E; negative elongation factor polypeptide E; NELF-E; nuclear protein; RD; RD RNA binding protein; RD RNA-binding protein; RDBP; RDP; RNA-binding protein RD
Orthologs:
Mus musculus (house mouse) : Nelfe (negative elongation factor complex member E, Rdbp)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nelfe (negative elongation factor complex member E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nelfe (negative elongation factor complex member E)
Pan paniscus (bonobo/pygmy chimpanzee) : NELFE (negative elongation factor complex member E)
Canis lupus familiaris (dog) : NELFE (negative elongation factor complex member E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nelfe (negative elongation factor complex member E)
Sus scrofa (pig) : NELFE (negative elongation factor complex member E)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,952,087 - 31,959,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,919,864 - 31,926,864 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,027,843 - 32,034,843 (-)NCBINCBI36hg18NCBI36
Build 34632,027,843 - 32,034,747NCBI
Celera633,519,627 - 33,526,530 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,706,833 - 31,713,834 (-)NCBIHuRef
CHM1_1631,921,945 - 31,928,945 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NELFE
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1344973
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.