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Gene: SLC7A8 (solute carrier family 7 member 8) Homo sapiens
Symbol: SLC7A8
Name: solute carrier family 7 member 8
Description: Exhibits amino acid transmembrane transporter activity; organic cation transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in amino acid transport. Localizes to the plasma membrane; PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hLAT2; integral membrane protein E16H; L-type amino acid transporter 2; large neutral amino acids transporter small subunit 2; LAT2; LPI-PC1; solute carrier family 7 (amino acid transporter light chain, L system), member 8; solute carrier family 7 (amino acid transporter, L-type), member 8; solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Mus musculus (house mouse) : Slc7a8 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc7a8 (solute carrier family 7 member 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc7a8 (solute carrier family 7 member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC7A8 (solute carrier family 7 member 8)
Canis lupus familiaris (dog) : SLC7A8 (solute carrier family 7 member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc7a8 (solute carrier family 7 member 8)
Sus scrofa (pig) : SLC7A8 (solute carrier family 7 member 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: LAT2 (Gene ID: 7462) and SLC7A8 (Gene ID: 23428) share the LAT2 symbol/alias in common. LAT2 is sometimes used as an alternative name for solute carrier family 7 member 8 (SLC7A8), which can be confused with the official symbol for linker for activation of T cells family member 2 (LAT2). [05 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1423,125,295 - 23,183,674 (-)Ensembl
GRCh381423,125,295 - 23,183,660 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371423,594,504 - 23,652,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,664,344 - 22,722,689 (-)NCBINCBI36hg18NCBI36
Build 341422,664,345 - 22,693,450NCBI
Celera143,457,210 - 3,515,570 (-)NCBI
Cytogenetic Map14q11.2NCBI
HuRef143,711,422 - 3,770,233 (-)NCBIHuRef
CHM1_11423,593,107 - 23,651,472 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC7A8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345085
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.