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Gene: KARS1 (lysyl-tRNA synthetase 1) Homo sapiens
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Symbol: KARS1
Name: lysyl-tRNA synthetase 1
Description: Exhibits ATP adenylyltransferase activity; lysine-tRNA ligase activity; and protein homodimerization activity. Involved in several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and positive regulation of cytokine production. Localizes to several cellular components, including the aminoacyl-tRNA synthetase multienzyme complex; extracellular space; and mitochondrion. Implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMTRIB; DFNB89; KARS; KARS2; KIAA0070; KRS; lysine tRNA ligase; lysine--tRNA ligase; lysRS; lysyl-tRNA synthetase
Orthologs:
Mus musculus (house mouse) : Kars (lysyl-tRNA synthetase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kars (lysyl-tRNA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kars1 (lysyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KARS1 (lysyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : KARS1 (lysyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kars1 (lysyl-tRNA synthetase 1)
Sus scrofa (pig) : KARS1 (lysyl-tRNA synthetase 1)
more info ...
Related Pseudogenes: KARS1P1   KARS1P2   KARS1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381675,627,724 - 75,647,687 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371675,661,622 - 75,681,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361674,219,131 - 74,239,078 (-)NCBINCBI36hg18NCBI36
Build 341674,219,130 - 74,239,078NCBI
Celera1659,955,969 - 59,975,930 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1661,415,299 - 61,435,262 (-)NCBIHuRef
CHM1_11677,074,018 - 77,093,985 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KARS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345099
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.