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Gene: KARS1 (lysyl-tRNA synthetase 1) Homo sapiens
Symbol: KARS1
Name: lysyl-tRNA synthetase 1
Description: Exhibits ATP adenylyltransferase activity; lysine-tRNA ligase activity; and protein homodimerization activity. Involved in several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and positive regulation of cytokine production. Localizes to several cellular components, including the aminoacyl-tRNA synthetase multienzyme complex; extracellular space; and mitochondrion. Implicated in Charcot-Marie-Tooth disease recessive intermediate B and autosomal recessive nonsyndromic deafness 89.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CMTRIB; DFNB89; KARS; KARS2; KIAA0070; KRS; lysine tRNA ligase; lysine--tRNA ligase; lysRS; lysyl-tRNA synthetase
Mus musculus (house mouse) : Kars (lysyl-tRNA synthetase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kars (lysyl-tRNA synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kars1 (lysyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : KARS1 (lysyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : KARS1 (lysyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kars1 (lysyl-tRNA synthetase 1)
Sus scrofa (pig) : KARS1 (lysyl-tRNA synthetase 1)
more info ...
Related Pseudogenes: KARS1P1   KARS1P2   KARS1P3  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381675,627,724 - 75,647,687 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371675,661,622 - 75,681,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361674,219,131 - 74,239,078 (-)NCBINCBI36hg18NCBI36
Build 341674,219,130 - 74,239,078NCBI
Celera1659,955,969 - 59,975,930 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1661,415,299 - 61,435,262 (-)NCBIHuRef
CHM1_11677,074,018 - 77,093,985 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KARS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345099
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.