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Gene: DUOX1 (dual oxidase 1) Homo sapiens
Symbol: DUOX1
Name: dual oxidase 1
Description: Predicted to have superoxide-generating NADPH oxidase activity. Involved in several processes, including cuticle development; hydrogen peroxide biosynthetic process; and response to cAMP. Localizes to several cellular components, including the cell leading edge; cell surface; and endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: flavoprotein NADPH oxidase; large NOX 1; LNOX1; long NOX 1; MGC138840; MGC138841; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; thyroid oxidase 1
Mus musculus (house mouse) : Duox1 (dual oxidase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Duox1 (dual oxidase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Duox1 (dual oxidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DUOX1 (dual oxidase 1)
Canis lupus familiaris (dog) : DUOX1 (dual oxidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Duox1 (dual oxidase 1)
Sus scrofa (pig) : DUOX1 (dual oxidase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1545,129,933 - 45,165,576 (+)Ensembl
GRCh381545,129,994 - 45,165,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371545,422,192 - 45,457,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,209,484 - 43,245,066 (+)NCBINCBI36hg18NCBI36
Build 341543,209,483 - 43,245,066NCBI
Celera1522,313,628 - 22,349,058 (+)NCBI
Cytogenetic Map15q21.1NCBI
HuRef1522,246,405 - 22,281,983 (+)NCBIHuRef
CHM1_11545,540,525 - 45,576,454 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DUOX1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345114
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.