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Gene: MYD88 (MYD88 innate immune signal transduction adaptor) Homo sapiens
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Symbol: MYD88
Name: MYD88 innate immune signal transduction adaptor
Description: Exhibits TIR domain binding activity; identical protein binding activity; and protein self-association. Involved in several processes, including defense response to other organism; positive regulation of cytokine production; and regulation of RNA metabolic process. Localizes to the cytoplasm and nucleus. Implicated in Waldenstroem's macroglobulinemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: mutant myeloid differentiation primary response 88; MYD88, innate immune signal transduction adaptor; MYD88D; myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response protein MyD88
Orthologs:
Mus musculus (house mouse) : Myd88 (myeloid differentiation primary response gene 88)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myd88 (MYD88, innate immune signal transduction adaptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myd88 (MYD88 innate immune signal transduction adaptor)
Pan paniscus (bonobo/pygmy chimpanzee) : MYD88 (MYD88 innate immune signal transduction adaptor)
Canis lupus familiaris (dog) : MYD88 (MYD88 innate immune signal transduction adaptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myd88 (MYD88 innate immune signal transduction adaptor)
Sus scrofa (pig) : MYD88 (MYD88 innate immune signal transduction adaptor)
Chlorocebus sabaeus (green monkey) : MYD88 (MYD88 innate immune signal transduction adaptor)
Heterocephalus glaber (naked mole-rat) : Myd88 (MYD88 innate immune signal transduction adaptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl338,138,478 - 38,143,022 (+)Ensembl
GRCh38338,138,661 - 38,143,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,179,969 - 38,184,513 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,155,009 - 38,159,517 (+)NCBINCBI36hg18NCBI36
Build 34338,155,156 - 38,159,514NCBI
Celera338,115,770 - 38,120,314 (+)NCBI
Cytogenetic Map3p22.2NCBI
HuRef338,220,931 - 38,225,475 (+)NCBIHuRef
CHM1_1338,131,949 - 38,136,493 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MYD88
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1345144
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.